منابع مشابه
The Basic Proteins of Cobra Venom
Cobra venoms contain heat stable, basic, proteins that inhibit iodide accumulation by thyroid slices. Activity is not related to the content of phospholipase A or various other enzymatic activities. These proteins are present only in Elapid venoms and not in snakes of the Crotalidae or Viperidae families. Two such basic proteins, named cobramines A and B, have been purified from the crude venom...
متن کاملThe basic proteins of cobra venom. II. Mechanism of action of cobramine B on thyroid tissue.
purified cobramine B from Nnja naja inhibits the accumulation of Iby thyroid and parotid slices or isolated choroid plexus. Accumulation of TcOland Re04 is also inhibited. The effect has a rapid onset, is temperature-dependent, and is prevented by polyanions or antivenom, but it is reversed with great difllculty, presumably because of very firm binding to tissue. Pretreatment with neuraminidase...
متن کاملThe basic proteins of cobra venom. I. Isolation and characterization of cobramines A and B.
Cobra venoms contain heat stable, basic, proteins that inhibit iodide accumulation by thyroid slices. Activity is not related to the content of phospholipase A or various other enzymatic activities. These proteins are present only in Elapid venoms and not in snakes of the Crotalidae or Viperidae families. Two such basic proteins, named cobramines A and B, have been purified from the crude venom...
متن کاملCobra Venom-induced Hemolysis
Interest in the alternate or C3 shunt complement pathway has recently been generated by a number of reports (1-5). Its presence in invertebrates points to a primitive phylogenetic appearance (6). The C3 shunt can be triggered by high molecular weight polysaccharides in a manner reminiscent of the properdin system (7). Once activated by cobra venom, erythrocytes and other cells can be lysed in t...
متن کاملCobra Venom in Therapeutics
During the past eight years the senior author has been engaged in testing the pharmacological action and therapeutic properties of Indian snake venoms. Chopra and Chowhan (1932 and 1935) showed that the efficacy of the cobra and other snake venoms in relieving the pain of malignant growths and of neuritis and neuralgias was probably due to the presence of such active principles as neurotoxin. The
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1968
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)56985-x